Complex Trait Genetics

Complex Trait Genetics Beyond Additivity

Forsberg, S. 2016. Complex Trait Genetics. Beyond Additivity. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1278. 45 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9754-5. The link between the genotype and the phenotype of an organism is immensely complex. Despite this it can, to a great extent, be captured using models that assume that gene...

Complex trait genetics in mice

Complex trait genetics of refractive error.

Refractive errors (myopia, hyperopia, and astigmatism) are complex heterogeneous disorders of the human eye and are ideal for genetic investigation. Moderate to severe refractive errors can predispose individuals to poor visual development, various types of glaucoma, misshapen corneal surfaces, premature cataracts, and loss of retinal integrity, which can lead to detachment. Knowledge of geneti...

Human Complex Trait Genetics in the 21st Century

I moved into the field of human complex trait genetics less than 20 years ago, from a background in quantitative genetics and animal breeding. Even in this period of time, major changes have occurred that were hard to predict back in the 1990s. Driven by enormous advances in DNA sequencing technologies, one can now sequence and analyze an entire human genome for a few thousand dollars. Some may...

Behavioural Genetics: Finding Genes that Cause Complex Trait Variation

Identifying genes that influence phenotypic variation is extremely difficult, especially when the allelic variants only have a small effect. A recent study has used a novel approach to identify a gene that affects the behaviour of mice.